Ecoepidemiology and Complete Genome Comparison of Different Strains of Severe Acute Respiratory Syndrome-Related Rhinolophus Bat Coronavirus in China Reveal Bats as a Reservoir for Acute, Self-Limiting Infection That Allows Recombination Events
Identifieur interne : 002942 ( Main/Exploration ); précédent : 002941; suivant : 002943Ecoepidemiology and Complete Genome Comparison of Different Strains of Severe Acute Respiratory Syndrome-Related Rhinolophus Bat Coronavirus in China Reveal Bats as a Reservoir for Acute, Self-Limiting Infection That Allows Recombination Events
Auteurs : Susanna K. P. Lau [Hong Kong] ; Kenneth S. M. Li [Hong Kong] ; YI HUANG [Hong Kong] ; Chung-Tong Shek [Hong Kong] ; Herman Tse [Hong Kong] ; MING WANG [République populaire de Chine] ; Garnet K. Y. Choi [Hong Kong] ; HUIFANG XU [République populaire de Chine] ; Carol S. F. Lam [Hong Kong] ; RONGTONG GUO [République populaire de Chine] ; Kwok-Hung Chan [Hong Kong] ; Bo-Jian Zheng [Hong Kong] ; Patrick C. Y. Woo [Hong Kong] ; Kwok-Yung Yuen [Hong Kong]Source :
- Journal of virology [ 0022-538X ] ; 2010.
Descripteurs français
- KwdFr :
- ARN viral (génétique), Animaux, Chine (épidémiologie), Chiroptera (virologie), Génome viral, Humains, Phylogénie, Recombinaison génétique, Réservoirs d'agents pathogènes (virologie), Syndrome respiratoire aigu sévère (virologie), Syndrome respiratoire aigu sévère (épidémiologie), Virus du SRAS (), Virus du SRAS (génétique).
- MESH :
- génétique : ARN viral, Virus du SRAS.
- virologie : Chiroptera, Réservoirs d'agents pathogènes, Syndrome respiratoire aigu sévère.
- épidémiologie : Chine, Syndrome respiratoire aigu sévère.
- Pascal (Inist)
- Wicri :
- geographic : République populaire de Chine.
English descriptors
- KwdEn :
- Acute, Animals, China (epidemiology), Chiroptera (virology), Coronavirus, Disease Reservoirs (virology), Genome, Genome, Viral, Humans, Phylogeny, RNA, Viral (genetics), Recombination, Recombination, Genetic, SARS Virus (classification), SARS Virus (genetics), Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (virology), Severe acute respiratory syndrome, Strain.
- MESH :
- chemical , genetics : RNA, Viral.
- geographic , epidemiology : China.
- classification : SARS Virus.
- epidemiology : Severe Acute Respiratory Syndrome.
- genetics : SARS Virus.
- virology : Chiroptera, Disease Reservoirs, Severe Acute Respiratory Syndrome.
- Animals, Genome, Viral, Humans, Phylogeny, Recombination, Genetic.
Abstract
Despite the identification of severe acute respiratory syndrome-related coronavirus (SARSr-CoV) in Rhinolophus Chinese horseshoe bats (SARSr-Rh-BatCoV) in China, the evolutionary and possible recombination origin of SARSr-CoV remains undetermined. We carried out the first study to investigate the migration pattern and SARSr-Rh-BatCoV genome epidemiology in Chinese horseshoe bats during a 4-year period. Of 1,401 Chinese horseshoe bats from Hong Kong and Guangdong, China, that were sampled, SARSr-Rh-BatCoV was detected in alimentary specimens from 130 (9.3%) bats, with peak activity during spring. A tagging exercise of 511 bats showed migration distances from 1.86 to 17 km. Bats carrying SARSr-Rh-BatCoV appeared healthy, with viral clearance occurring between 2 weeks and 4 months. However, lower body weights were observed in bats positive for SARSr-Rh-BatCoV, but not Rh-BatCoV HKU2. Complete genome sequencing of 10 SARSr-Rh-BatCoV strains showed frequent recombination between different strains. Moreover, recombination was detected between SARSr-Rh-BatCoV Rp3 from Guangxi, China, and Rf1 from Hubei, China, in the possible generation of civet SARSr-CoV SZ3, with a breakpoint at the nsp16/spike region. Molecular clock analysis showed that SARSr-CoVs were newly emerged viruses with the time of the most recent common ancestor (tMRCA) at 1972, which diverged between civet and bat strains in 1995. The present data suggest that SARSr-Rh-BatCoV causes acute, self-limiting infection in horseshoe bats, which serve as a reservoir for recombination between strains from different geographical locations within reachable foraging range. Civet SARSr-CoV is likely a recombinant virus arising from SARSr-CoV strains closely related to SARSr-Rh-BatCoV Rp3 and Rfl. Such frequent recombination, coupled with rapid evolution especially in ORF7b/ORF8 region, in these animals may have accounted for the cross-species transmission and emergence of SARS.
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Li</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Microbiology, The University of Hong Kong</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Yi Huang" sort="Yi Huang" uniqKey="Yi Huang" last="Yi Huang">YI HUANG</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Microbiology, The University of Hong Kong</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Shek, Chung Tong" sort="Shek, Chung Tong" uniqKey="Shek C" first="Chung-Tong" last="Shek">Chung-Tong Shek</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Agriculture, Fisheries and Conservation, The Government of Hong Kong Special Administrative Region</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>4 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Tse, Herman" sort="Tse, Herman" uniqKey="Tse H" first="Herman" last="Tse">Herman Tse</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Research Centre of Infection and Immunology, The University of Hong Kong</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Carol Yu Centre for Infection, The University of Hong Kong</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Microbiology, The University of Hong Kong</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Ming Wang" sort="Ming Wang" uniqKey="Ming Wang" last="Ming Wang">MING WANG</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Guangzhou Center for Disease Control and Prevention</s1><s2>Guangzhou</s2><s3>CHN</s3><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Choi, Garnet K Y" sort="Choi, Garnet K Y" uniqKey="Choi G" first="Garnet K. Y." last="Choi">Garnet K. Y. Choi</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Microbiology, The University of Hong Kong</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Huifang Xu" sort="Huifang Xu" uniqKey="Huifang Xu" last="Huifang Xu">HUIFANG XU</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Guangzhou Center for Disease Control and Prevention</s1><s2>Guangzhou</s2><s3>CHN</s3><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Lam, Carol S F" sort="Lam, Carol S F" uniqKey="Lam C" first="Carol S. 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Y." last="Woo">Patrick C. Y. Woo</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Research Centre of Infection and Immunology, The University of Hong Kong</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Carol Yu Centre for Infection, The University of Hong Kong</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation 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Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Carol Yu Centre for Infection, The University of Hong Kong</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Microbiology, The University of Hong Kong</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">10-0244387</idno><date 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P." last="Lau">Susanna K. P. Lau</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Research Centre of Infection and Immunology, The University of Hong Kong</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Carol Yu Centre for Infection, The University of Hong Kong</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Microbiology, The University of Hong Kong</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Li, Kenneth S M" sort="Li, Kenneth S M" uniqKey="Li K" first="Kenneth S. M." last="Li">Kenneth S. M. Li</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Microbiology, The University of Hong Kong</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Yi Huang" sort="Yi Huang" uniqKey="Yi Huang" last="Yi Huang">YI HUANG</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Microbiology, The University of Hong Kong</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Shek, Chung Tong" sort="Shek, Chung Tong" uniqKey="Shek C" first="Chung-Tong" last="Shek">Chung-Tong Shek</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Agriculture, Fisheries and Conservation, The Government of Hong Kong Special Administrative Region</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>4 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Tse, Herman" sort="Tse, Herman" uniqKey="Tse H" first="Herman" last="Tse">Herman Tse</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Research Centre of Infection and Immunology, The University of Hong Kong</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Carol Yu Centre for Infection, The University of Hong Kong</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Microbiology, The University of Hong Kong</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Ming Wang" sort="Ming Wang" uniqKey="Ming Wang" last="Ming Wang">MING WANG</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Guangzhou Center for Disease Control and Prevention</s1><s2>Guangzhou</s2><s3>CHN</s3><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Choi, Garnet K Y" sort="Choi, Garnet K Y" uniqKey="Choi G" first="Garnet K. Y." last="Choi">Garnet K. Y. Choi</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Microbiology, The University of Hong Kong</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Huifang Xu" sort="Huifang Xu" uniqKey="Huifang Xu" last="Huifang Xu">HUIFANG XU</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Guangzhou Center for Disease Control and Prevention</s1><s2>Guangzhou</s2><s3>CHN</s3><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Lam, Carol S F" sort="Lam, Carol S F" uniqKey="Lam C" first="Carol S. F." last="Lam">Carol S. F. Lam</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Microbiology, The University of Hong Kong</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Rongtong Guo" sort="Rongtong Guo" uniqKey="Rongtong Guo" last="Rongtong Guo">RONGTONG GUO</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Guangzhou Center for Disease Control and Prevention</s1><s2>Guangzhou</s2><s3>CHN</s3><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Chan, Kwok Hung" sort="Chan, Kwok Hung" uniqKey="Chan K" first="Kwok-Hung" last="Chan">Kwok-Hung Chan</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Microbiology, The University of Hong Kong</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Zheng, Bo Jian" sort="Zheng, Bo Jian" uniqKey="Zheng B" first="Bo-Jian" last="Zheng">Bo-Jian Zheng</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Microbiology, The University of Hong Kong</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Woo, Patrick C Y" sort="Woo, Patrick C Y" uniqKey="Woo P" first="Patrick C. Y." last="Woo">Patrick C. Y. Woo</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Research Centre of Infection and Immunology, The University of Hong Kong</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Carol Yu Centre for Infection, The University of Hong Kong</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Microbiology, The University of Hong Kong</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Research Centre of Infection and Immunology, The University of Hong Kong</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Carol Yu Centre for Infection, The University of Hong Kong</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Microbiology, The University of Hong Kong</s1><s2>Hong Kong</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Journal of virology</title><title level="j" type="abbreviated">J. virol.</title><idno type="ISSN">0022-538X</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of virology</title><title level="j" type="abbreviated">J. virol.</title><idno type="ISSN">0022-538X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute</term><term>Animals</term><term>China (epidemiology)</term><term>Chiroptera (virology)</term><term>Coronavirus</term><term>Disease Reservoirs (virology)</term><term>Genome</term><term>Genome, Viral</term><term>Humans</term><term>Phylogeny</term><term>RNA, Viral (genetics)</term><term>Recombination</term><term>Recombination, Genetic</term><term>SARS Virus (classification)</term><term>SARS Virus (genetics)</term><term>Severe Acute Respiratory Syndrome (epidemiology)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Severe acute respiratory syndrome</term><term>Strain</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (génétique)</term><term>Animaux</term><term>Chine (épidémiologie)</term><term>Chiroptera (virologie)</term><term>Génome viral</term><term>Humains</term><term>Phylogénie</term><term>Recombinaison génétique</term><term>Réservoirs d'agents pathogènes (virologie)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Syndrome respiratoire aigu sévère (épidémiologie)</term><term>Virus du SRAS ()</term><term>Virus du SRAS (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>China</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN viral</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Chiroptera</term><term>Réservoirs d'agents pathogènes</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Chiroptera</term><term>Disease Reservoirs</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Chine</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Genome, Viral</term><term>Humans</term><term>Phylogeny</term><term>Recombination, Genetic</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Animaux</term><term>Coronavirus</term><term>Génome</term><term>Génome viral</term><term>Humains</term><term>Phylogénie</term><term>Recombinaison génétique</term><term>Souche</term><term>Aigu</term><term>Recombinaison</term><term>Syndrome respiratoire aigu sévère</term><term>Virus du SRAS</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Despite the identification of severe acute respiratory syndrome-related coronavirus (SARSr-CoV) in Rhinolophus Chinese horseshoe bats (SARSr-Rh-BatCoV) in China, the evolutionary and possible recombination origin of SARSr-CoV remains undetermined. We carried out the first study to investigate the migration pattern and SARSr-Rh-BatCoV genome epidemiology in Chinese horseshoe bats during a 4-year period. Of 1,401 Chinese horseshoe bats from Hong Kong and Guangdong, China, that were sampled, SARSr-Rh-BatCoV was detected in alimentary specimens from 130 (9.3%) bats, with peak activity during spring. A tagging exercise of 511 bats showed migration distances from 1.86 to 17 km. Bats carrying SARSr-Rh-BatCoV appeared healthy, with viral clearance occurring between 2 weeks and 4 months. However, lower body weights were observed in bats positive for SARSr-Rh-BatCoV, but not Rh-BatCoV HKU2. Complete genome sequencing of 10 SARSr-Rh-BatCoV strains showed frequent recombination between different strains. Moreover, recombination was detected between SARSr-Rh-BatCoV Rp3 from Guangxi, China, and Rf1 from Hubei, China, in the possible generation of civet SARSr-CoV SZ3, with a breakpoint at the nsp16/spike region. Molecular clock analysis showed that SARSr-CoVs were newly emerged viruses with the time of the most recent common ancestor (tMRCA) at 1972, which diverged between civet and bat strains in 1995. The present data suggest that SARSr-Rh-BatCoV causes acute, self-limiting infection in horseshoe bats, which serve as a reservoir for recombination between strains from different geographical locations within reachable foraging range. Civet SARSr-CoV is likely a recombinant virus arising from SARSr-CoV strains closely related to SARSr-Rh-BatCoV Rp3 and Rfl. Such frequent recombination, coupled with rapid evolution especially in ORF7b/ORF8 region, in these animals may have accounted for the cross-species transmission and emergence of SARS.</div></front></TEI><affiliations><list><country><li>Hong Kong</li><li>République populaire de Chine</li></country><region><li>Guangdong</li></region><settlement><li>Jiangmen</li></settlement></list><tree><country name="Hong Kong"><noRegion><name sortKey="Lau, Susanna K P" sort="Lau, Susanna K P" uniqKey="Lau S" first="Susanna K. P." last="Lau">Susanna K. P. Lau</name></noRegion><name sortKey="Chan, Kwok Hung" sort="Chan, Kwok Hung" uniqKey="Chan K" first="Kwok-Hung" last="Chan">Kwok-Hung Chan</name><name sortKey="Choi, Garnet K Y" sort="Choi, Garnet K Y" uniqKey="Choi G" first="Garnet K. Y." last="Choi">Garnet K. Y. Choi</name><name sortKey="Lam, Carol S F" sort="Lam, Carol S F" uniqKey="Lam C" first="Carol S. F." last="Lam">Carol S. F. Lam</name><name sortKey="Lau, Susanna K P" sort="Lau, Susanna K P" uniqKey="Lau S" first="Susanna K. P." last="Lau">Susanna K. P. Lau</name><name sortKey="Lau, Susanna K P" sort="Lau, Susanna K P" uniqKey="Lau S" first="Susanna K. P." last="Lau">Susanna K. P. Lau</name><name sortKey="Lau, Susanna K P" sort="Lau, Susanna K P" uniqKey="Lau S" first="Susanna K. P." last="Lau">Susanna K. P. Lau</name><name sortKey="Li, Kenneth S M" sort="Li, Kenneth S M" uniqKey="Li K" first="Kenneth S. M." last="Li">Kenneth S. M. Li</name><name sortKey="Shek, Chung Tong" sort="Shek, Chung Tong" uniqKey="Shek C" first="Chung-Tong" last="Shek">Chung-Tong Shek</name><name sortKey="Tse, Herman" sort="Tse, Herman" uniqKey="Tse H" first="Herman" last="Tse">Herman Tse</name><name sortKey="Tse, Herman" sort="Tse, Herman" uniqKey="Tse H" first="Herman" last="Tse">Herman Tse</name><name sortKey="Tse, Herman" sort="Tse, Herman" uniqKey="Tse H" first="Herman" last="Tse">Herman Tse</name><name sortKey="Tse, Herman" sort="Tse, Herman" uniqKey="Tse H" first="Herman" last="Tse">Herman Tse</name><name sortKey="Woo, Patrick C Y" sort="Woo, Patrick C Y" uniqKey="Woo P" first="Patrick C. Y." last="Woo">Patrick C. Y. Woo</name><name sortKey="Woo, Patrick C Y" sort="Woo, Patrick C Y" uniqKey="Woo P" first="Patrick C. Y." last="Woo">Patrick C. Y. Woo</name><name sortKey="Woo, Patrick C Y" sort="Woo, Patrick C Y" uniqKey="Woo P" first="Patrick C. Y." last="Woo">Patrick C. Y. Woo</name><name sortKey="Woo, Patrick C Y" sort="Woo, Patrick C Y" uniqKey="Woo P" first="Patrick C. Y." last="Woo">Patrick C. Y. Woo</name><name sortKey="Yi Huang" sort="Yi Huang" uniqKey="Yi Huang" last="Yi Huang">YI HUANG</name><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name><name sortKey="Zheng, Bo Jian" sort="Zheng, Bo Jian" uniqKey="Zheng B" first="Bo-Jian" last="Zheng">Bo-Jian Zheng</name></country><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Ming Wang" sort="Ming Wang" uniqKey="Ming Wang" last="Ming Wang">MING WANG</name></region><name sortKey="Huifang Xu" sort="Huifang Xu" uniqKey="Huifang Xu" last="Huifang Xu">HUIFANG XU</name><name sortKey="Rongtong Guo" sort="Rongtong Guo" uniqKey="Rongtong Guo" last="Rongtong Guo">RONGTONG GUO</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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